The aim is to obtain a specific serological test that can be used for high-throughput testing for Covid-19 infection. Aim: Identification of antiviral molecules targeting SARS-CoV2 proteases. With its new "Omics" buildings, the Institut Pasteur continues its digital revolution, Yellow fever: a new method for testing vaccine safety, Zika: an accurate estimation of the neurological risks in unborn children, Zika: silent long-term circulation in Thailand, All SARS-CoV-2 / COVID-19 from the Institut Pasteur, A SARS-CoV-2 genome sequencing technique to analyze low-quality clinical samples, A combination of cutting-edge proteomic approaches for improving understanding of SARS-CoV-2 infection mechanisms, A technique to identify key cellular factors for SARS-CoV-2 infection, A zebrafish model to study SARS-CoV-2 neuroinvasion, Accelerating the identification & design of SARS-CoV2 antiviral drugs in combination with the “DrugDesign_SARS2” project, Antibody profiling in recovering patients and development of a serological test for an epidemiological survey in individuals exposed to SARS-CoV-2, Building a collection of human biological samples in France, Characterization of interaction between SARS-CoV-2 Nsp3 protein and non-canonical nucleic acid structures (G4) present in infected cells, Characterization of variable systemic and mucosal immunity during SARS-CoV-2 infection and recovery, Covid-19 risk evaluation among the household contacts of the first cases in Africa, Covid-19: A vaccine candidate using a lentiviral vector, Covid-19: vaccine against SARS-CoV-2 infection, using the measles vector, Deciphering the virus interactions with the entry receptors in human cells, and their potential inhibition, Defective viral genomes (DVGs), potential antiviral inhibitors of SARS-CoV-2, Descriptive study: epidemiological, clinical and immunological analysis of SARS-CoV-2 cases in the Metropolitan Region of São Paulo, Brazil, Developing a rapid diagnostic test to detect SARS-CoV2 virus in various environment, Development of an animal model and accelerated development of a DNA vaccine candidate, Development of novel nano-based multi-epitope vaccine against coronavirus SARS-CoV-2 - Generation of Humanized NSG transfer mouse model for vaccine testingAim: We hypothesize that it may be possible to generate protective anti-SARS-CoV-2 immuneresponse in, Development of simple Covid-19 serological tools and targeted serosurvey of at-risk individuals, Drug Repurposing & Design to inhibit the SARS-CoV2 proteases, Engineering an ACE2 derived polypeptide for label-free, real-time detection on a smartphone device and therapeutic intervention, Evaluating the determinants of coronavirus tropism in 3D models of human pulmonary epithelia, Evaluation of SARS-CoV-2 infection spread in various populations groups in Cameroon, Evaluation of clinical presentation and evolution of SARS -CoV-2 coronavirus infection in Senegal, Evolution of SARS-CoV-2 and the antibody immune response in humans during infection, Find potent antiviral drugs against SARS-CoV2 by targeting well identified proteins essential to the viral cycle, Generation of animal models sensitive to SARS-CoV-2 to test vaccines or drugs, Household transmission investigation study for SARS in overseas territories, Identification and isolation of potent human neutralizing antibodies against SARS-CoV-2, Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection, Investigating the role of apico-basal proteins during SARS-Cov2 infection, Investigation of the first cases of coronavirus (COVID-19) infections and their contacts in Antananarivo, Madagascar, Isolating and characterizing the human antibodies that neutralize SARS-CoV-2, Mechanisms of intercellular spreading of SARS-CoV-2: assessing the role of TNTs to escape immune surveillance and expand tropism and pathogenicity, Modeling human SARS-CoV-2 infection in mice with human lung xenografts, Monitoring the origins and transmission/spread of SARS-CoV-2 in Laos and Vietnam: searching for SARS-like viruses and detecting antibodies in vertebrates, Neurological implications of SARS-COV-2 infection – a transversal study, Nicotinic modulation of SARS-CoV-2 infection in the brain, Origins, natural reservoirs and interspecies transmission of SARS-CoV-2 and other SARS-like coronaviruses, Production of recombinant antigens from two SARS-CoV-2 proteins and generation of nano-antibodies against these proteins for diagnostic and therapeutic applications, Profiling SARS-CoV-2 intra-viral and virus-host interactions on the basis of innate immunity signaling, Protocol for assessment of potential risk factors for 2019-novel coronavirus (2019-nCoV) infection among health care workers in a health care setting, Randomized trial of Covid-19 chemoprophylaxis in healthcare professionals, Red Cross health workers and volunteers and continuity of care with COVID-19: an operational approach using mixed methods, Restriction of SARS-CoV-2 replication by coding and non-coding genes, SARS-CoV-2 fusion, replication and host responses, Sequence the complete genome of Covid-19 directly and at low cost from prepared RNA samples from patients, Serological surveillance of SARS-CoV-2 and seasonal coronaviruses, Short Amplicon Based Sequencing Of SARS-CoV-2 for low-input samples, Spike glycoprotein, lentiviral vectors and B/T-cell vaccine, The use of Artificial Intelligence Methods to Discriminate Covid-19 from other Community Acquired Pneumopathy using Chest X-Ray and CT images, Urgent Discovery of Drug Candidates That Target Coronavirus SARS-CoV-2, Working towards controlled detection of SARS-CoV-2 by the innate immune system, rBCG vaccine secreting SARS-CoV-2 antigens, Global Health at the Human-Animal-Ecosystem Interface, MOOC Concepts and Methods in Epidemiology - 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Post Contract and Strategic Alliance, Technology Transfer and Industrial Partnership. Results of this project will provide clues on whether targeting potential neurotropism of CoV-2 may be relevant approach for experimental therapeutics in Covid-19. This study aims to obtain an early understanding of key epidemiological characteristics in the family contacts in different African countries of the IPIN to inform decision makers about the potential spread and impact of SARS-CoV-2 infection in the closest contacts. Structures of the proteases will be used to screen large chemical libraries in complement of the FDA approved drugs. This protocol can be carried out in 15 minutes and is simple in its implementation. It is intended to follow confirmed infected cases and their household members. Aim: This study aims to understand the epidemiologic, clinical, virologic and immunologic characteristics of first infected cases, their evolution and household transmission. People with symptoms of Covid-19 cannot be tested and are asked to go to the hospital or call the emergency medical services (190) The idea is to generate the following unique tools as quickly as possible: recombinant SARS-CoV-2 nucleoprotein (N) and spike (S) antigens; nano-antibodies targeting these two proteins. Prototypes will be sent to world-leading labs in UK, Senegal, Spain, China, Malaysia and Brazil for priority validation. Will this Senegalese $1 test stick be a game-changer for Covid-19 detection? This research particularly concerns lung cells, the main targets of the virus. The … DVGs are defective viral genomes capable of hijacking the replication machinery of wild-type viruses and partially or totally inhibiting viral populations. The project complements (and it is conducted in conjunction with) a project at the Institut Pasteur du Laos: "Origins, natural reservoirs and interspecies transmission of SARS-CoV-2 and other SARS-like coronaviruses" (ONRITS) (see project 12), which aims to improve understanding of the origins, natural history and dissemination of SARS-CoV-2 and other SARS-like CoVs in their natural environment, as well as potential bat-to-bat, bat-to-animal and bat-to-human transmission mechanisms. National Institute of Public Health joins the fight against COVID-19 in Cambodia. Dans le cadre de la contribution à la riposte à l’épidémie de COVID-19, l’Institut Pasteur de Côte d’Ivoire mène une enquête sur les connaissances, perceptions et pratiques préventives des populations vis-à-vis du COVID-19. This will be achieved by administering to them of lipid-based nanoparticles carrying peptide molecules, comprising dominant immunogenic B and T cell epitopes from coronavirus SARS-CoV-2. This is how the Cov2-Pls-project researchers will develop a high-throughput screening system to identify inhibitors that can effectively block the action of SARS-CoV-2 proteases, and thus stop the proliferation of the virus. The injected DNA triggers a protective immunological response, for example the production of antibodies against the antigen. These simple, low-cost assays are therefore easy to use for detecting SARS-CoV-2 in samples taken in the field. The Research Journal: 2018's most read articles! Current RT-PCR-based assays are ultra-sensitive, but also expensive and therefore inaccessible to the poorest countries. Covid : BioSpeedia arrive sur le marché français du test diagnostic. Aim: to improve understanding of the origins, natural history and dissemination of SARS-CoV-2 and SARS-like coronaviruses in their natural environment. ARISE deals with the development and validation of an analytical chain for the air monitoring of areas at risk of exposure to individuals contaminated by the SARS-CoV2 virus. Blood test: a potential new tool for controlling infections, Book release: “Institut Pasteur: Today's Research, Tomorrow's Medicine”, COVID-19 - The Bioinformatics and Biostatistics Hub on the front line, COVID-19, chronicle of an expected pandemic / Exiting lockdown or the sum total of all dangers, COVID-19: Senlis Criminal Court convicts the author of a fake news video for defamation, COVID-19: the latest on the epidemic situation and why caution is still needed, Catherine Rougeot and the discovery of a new painkiller molecule, Cellular therapy: identification of circulating human Innate Lymphoid Cell Precursors, Central nervous system infections: how group B streptococci cross the blood-brain barrier, Ceremony for the 2019 Pasteur Vallery-Radot Prize (awarded by the BnF), Chaos in ageing skeletal muscle stem cells, Chikungunya spreads in and around homes with women at highest risk, Chikungunya: the specific interactions between the genotypes of mosquitoes and viruses have influenced Ae. But sequencing can be difficult because of poor quality samples or the low ratio of viral to host RNA. Why does bronchiolitis only affect infants? Diphtheria: identification of a penicillin resistance gene, Discovery of a mechanism responsible for chronic inflammation in patients suffering from multiple sclerosis, Discovery of a restriction factor for hepatitis B virus, Discovery of new strains of the HTLV-4 virus in hunters bitten by gorillas in Gabon, Discovery of the mechanism used to coordinate replication of the two Vibrio cholerae chromosomes, Distinguishing resistence from resilience to prolong antibiotic potency, Division – a key moment in establishing cell polarity, Drastic reduction of exposure to malaria in Senegal, EDF Group Foundation supports the Institut Pasteur and the DIVA project, ERC grants: scientific excellence supported by Europe, Ebola: the answers to your questions in our disease sheet, Economist Jim O’Neill, and other experts, discuss Antimicrobial Resistance at the Institut Pasteur, Effect of the seasons on pneumococcal infections, Efficacy of cancer treatment: two bacteria in the microbiota identified, Embryonic development – the role of Nodal in establishing cardiac asymmetry, Esrrb transcription factor plays a key role in maintaining stem cell identity even after countless divisions, Establishment of the Hearing Institute, a new Institut Pasteur center: scientific experts within the field of hearing brought together for a high-level international meeting, Exhibition in honor of Jules Bordet at the Université libre de Bruxelles.
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